Neuropathology of Parkinsonism
نویسنده
چکیده
The common denominator of virtually all disorders associated with clinical parkinsonism is neuronal loss in the substantia nigra, particularly of dopaminergic neurons in the pars compacta that project to the striatum (Fig. 1). The ventrolateral tier of neurons appears to be the most vulnerable in many parkinsonian disorders, and these tend to project heavily to the putamen (1). The more medial groups of neurons send projections to forebrain and medial temporal lobe and are less affected. The dorsal tier of neurons may be most vulnerable to neuronal loss associated with aging (1).
منابع مشابه
Neuropathology of Atypical Parkinsonian Disorders
Although the clinical syndrome of parkinsonism (rigidity, bradykinesia, and tremor) is most often owing to idiopathic Parkinson’s disease (PD), it may also be associated with a variety of other underlying pathologies (Table 1) (1–3). Each of these other pathological conditions tends to have a characteristic clinical phenotype, however atypical cases are increasingly recognized (4–8). Moreover, ...
متن کاملThe Australian and New Zealand Society for Neuropathology
s: * Presentations marked with an * are eligible for “The Bill Evans Memorial Award” for Young Investigators. INVITED INTERNATIONAL SPEAKER: Title: Recent Advances in the Neuropathology and Genetics of Parkinsonism and Dementia with Lewy
متن کاملThe neuropathology of manganese-induced Parkinsonism.
Manganese is an essential trace metal that is widely used in industry, particularly in the manufacture of steel. Exposure to high levels of manganese can cause neurotoxicity with the development of a form of parkinsonism known as manganism. It has recently been hypothesized that manganese exposure might also cause or accelerate the development of Parkinson disease (PD). This article is a review...
متن کاملParkinsonism--neuropathology.
for willed movements only, but subsequently also for following movements and the upward movement of the eyeballs which occurs on closing the lids. At a later stage, lateral conjugate gaze is also affected, the loss again first involving voluntary movements and at a later stage reflexly induced or following movements. Tremor is not a feature of this condition, which is unlikely to be missed if o...
متن کاملNigral pathology and parkinsonian signs in elders without Parkinson disease.
OBJECTIVE Motor symptoms such as mild parkinsonian signs are common in older persons, but little is known about their underlying neuropathology. We tested the hypothesis that nigral pathology is related to parkinsonism in older persons without Parkinson disease (PD). METHODS More than 2,500 persons participating in the Religious Orders Study or the Memory and Aging Project agreed to annual as...
متن کاملGenetic Identification Is Critical for the Diagnosis of Parkinsonism: A Chinese Pedigree with Early Onset of Parkinsonism
BACKGROUND A number of hereditary neurological diseases display indistinguishable features at the early disease stage. Parkinsonian symptoms can be found in numerous diseases, making it difficult to get a definitive early diagnosis of primary causes for patients with onset of parkinsonism. The accurate and early diagnosis of the causes of parkinsonian patients is important for effective treatme...
متن کامل